ABSTRACT
UV-vis and impedance measurements were performed to determine the stable formation of the Hydroxychloroquine-Zinc (HCQ-Zn) complex within the oleic acid (oil) phase of the oil-water system. Decreased UV absorbance with increased Zn concentration was associated with the gradual formation of the complexes within the oil phase, agreeing with existing reports and our time-dependent-density-functional calculations. The reproducibility of our data over a long period indicates the stability of the complex within the oil phase. The impedance measurement showed that the dielectric loss of the oil phase due to the polarization of the complex is less than that due to the polarization of HCQ. A basic impedance measurement revealed that the aqueous-to-oil transfer of Zn is not possible without the HCQ, a result pertinent to the recent report that HCQ is Zn ionophore. Our work is thus important to the fundamental physical chemistry and the current COVID-19 issue where the Zn infusion across the living cell phospholipid membrane (mimicked as an oil-water interface) reduces viral replication. © 2021 Elsevier B.V.
ABSTRACT
Following the COVID 19 pandemic outbreak, mental health and wellbeing of employed women are at stake. The Movement Control Order (MCO) has forced the majority employed women to play multiple roles in a 24/7 situation with little break if ever for her own self-care. Therefore, we propose a new employment scheme called DAMAI (Domestic Assistant Malaysian Affectionate Initiative) along with mobile and web applications online housekeepers and caregivers to improve the well-being of working women by including computer implemented genogram as mental health screening. To provide a comprehensive solution to the problem, human ecological theory, family systems theory and women well-being model are discussed. While the theory of planned behavior (TBP) and technology acceptance models are referred to in the development of web and mobile applications called MyDAMAI HOME. Finally, the presentation of the Mock Up MyDAMAI Home mark the end this paper with conclusion. © 2020 by Advance Scientific Research. This is an open-access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)